Autophagy-mediated catabolism of visual transduction proteins prevents retinal degeneration

Autophagy is a lysosomal degradation pathway critical to preventing the accumulation of cytotoxic proteins. Deletion of the essential autophagy gene Atg5 from the rod photoreceptors of the retina (atg5(Δrod) mouse) results in the accumulation of the phototransduction protein transducin and the degen...

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Dades bibliogràfiques
Publicat a:Autophagy
Autors principals: Yao, Jingyu, Jia, Lin, Feathers, Kecia, Lin, Chengmao, Khan, Naheed W., Klionsky, Daniel J., Ferguson, Thomas A., Zacks, David N.
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2016
Matèries:
Basic Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5173283/
https://ncbi.nlm.nih.gov/pubmed/27753525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1238553
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