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Preclinical effects of CRLX101, an investigational camptothecin-containing nanoparticle drug conjugate, on treating glioblastoma multiforme via apoptosis and antiangiogenesis

Malignant gliomas are difficult to treat in clinical practice. This study was aimed to investigate the preclinical efficacy of CRLX101, an investigational nanoparticle-drug conjugate developed by conjugating camptothecin (CPT) with cyclodextrin-polyethylene glycol, against gliomas. CPT fluorescence...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Lin, Chien-Ju, Lin, Yi-Ling, Luh, Frank, Yen, Yun, Chen, Ruei-Ming
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5173144/
https://ncbi.nlm.nih.gov/pubmed/27285755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9878
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