Preclinical Results of Camptothecin-Polymer Conjugate (IT-101) in Multiple Human Lymphoma Xenograft Models

PURPOSE: Camptothecin (CPT) has potent broad spectrum antitumor activity by inhibiting type I DNA topoisomerase (DNA topo I). It has not been used clinically because it is water-insoluble and highly toxic. As a result, irinotecan (CPT-11), a water-soluble analogue of CPT, has been developed and used...

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Autori principali: Numbenjapon, Tontanai, Wang, Jianyi, Colcher, David, Schluep, Thomas, Davis, Mark E., Duringer, Julienne, Kretzner, Leo, Yen, Yun, Forman, Stephen J., Raubitschek, Andrew
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245217/
https://ncbi.nlm.nih.gov/pubmed/19549776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-2619
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