Constitutively active transforming growth factor β receptor 1 in the mouse ovary promotes tumorigenesis

Despite the well-established tumor suppressive role of TGFβ proteins, depletion of key TGFβ signaling components in the mouse ovary does not induce a growth advantage. To define the role of TGFβ signaling in ovarian tumorigenesis, we created a mouse model expressing a constitutively active TGFβ rece...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Gao, Yang, Vincent, David F., Davis, Anna Jane, Sansom, Owen J., Bartholin, Laurent, Li, Qinglei
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Priority Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5173031/
https://ncbi.nlm.nih.gov/pubmed/27344183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10149
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