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Transport of lipophilic carboxylates is mediated by transmembrane helix 2 in multidrug transporter AcrB

The deployment of multidrug efflux pumps is a powerful defence mechanism for Gram-negative bacterial cells when exposed to antimicrobial agents. The major multidrug efflux transport system in Escherichia coli, AcrAB–TolC, is a tripartite system using the proton-motive force as an energy source. The...

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Pubblicato in:Nat Commun
Autori principali: Oswald, Christine, Tam, Heng-Keat, Pos, Klaas M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5171871/
https://ncbi.nlm.nih.gov/pubmed/27982032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13819
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