A high-throughput small molecule screen identifies synergism between DNA methylation and Aurora kinase pathways for X reactivation

X-chromosome inactivation is a mechanism of dosage compensation in which one of the two X chromosomes in female mammals is transcriptionally silenced. Once established, silencing of the inactive X (Xi) is robust and difficult to reverse pharmacologically. However, the Xi is a reservoir of >1,000...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Lessing, Derek, Dial, Thomas O., Wei, Chunyao, Payer, Bernhard, Carrette, Lieselot L. G., Kesner, Barry, Szanto, Attila, Jadhav, Ajit, Maloney, David J., Simeonov, Anton, Theriault, Jimmy, Hasaka, Thomas, Bedalov, Antonio, Bartolomei, Marisa S., Lee, Jeannie T.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2016
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5167172/
https://ncbi.nlm.nih.gov/pubmed/28182563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1617597113
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak