A high-throughput small molecule screen identifies synergism between DNA methylation and Aurora kinase pathways for X reactivation

X-chromosome inactivation is a mechanism of dosage compensation in which one of the two X chromosomes in female mammals is transcriptionally silenced. Once established, silencing of the inactive X (Xi) is robust and difficult to reverse pharmacologically. However, the Xi is a reservoir of >1,000...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Lessing, Derek, Dial, Thomas O., Wei, Chunyao, Payer, Bernhard, Carrette, Lieselot L. G., Kesner, Barry, Szanto, Attila, Jadhav, Ajit, Maloney, David J., Simeonov, Anton, Theriault, Jimmy, Hasaka, Thomas, Bedalov, Antonio, Bartolomei, Marisa S., Lee, Jeannie T.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5167172/
https://ncbi.nlm.nih.gov/pubmed/28182563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1617597113
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