Rapamycin rescues vascular, metabolic and learning deficits in apolipoprotein E4 transgenic mice with pre-symptomatic Alzheimer’s disease

Apolipoprotein E ɛ4 allele is a common susceptibility gene for late-onset Alzheimer's disease. Brain vascular and metabolic deficits can occur in cognitively normal apolipoprotein E ɛ4 carriers decades before the onset of Alzheimer's disease. The goal of this study was to determine whether...

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Detalhes bibliográficos
Publicado no:J Cereb Blood Flow Metab
Main Authors: Lin, Ai-Ling, Jahrling, Jordan B, Zhang, Wei, DeRosa, Nicholas, Bakshi, Vikas, Romero, Peter, Galvan, Veronica, Richardson, Arlan
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2015
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5167110/
https://ncbi.nlm.nih.gov/pubmed/26721390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X15621575
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