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Human leucocyte antigen class I‐redirected anti‐tumour CD4(+) T cells require a higher T cell receptor binding affinity for optimal activity than CD8(+) T cells
CD4(+) T helper cells are a valuable component of the immune response towards cancer. Unfortunately, natural tumour‐specific CD4(+) T cells occur in low frequency, express relatively low‐affinity T cell receptors (TCRs) and show poor reactivity towards cognate antigen. In addition, the lack of human...
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| Publicado no: | Clin Exp Immunol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5167017/ https://ncbi.nlm.nih.gov/pubmed/27324616 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cei.12828 |
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