Lipopolysaccharide Interaction with Cell Surface Toll-like Receptor 4-MD-2: Higher Affinity than That with MD-2 or CD14

Toll-like receptors (TLRs) are innate recognition molecules for microbial products, but their direct interactions with corresponding ligands remain unclarified. LPS, a membrane constituent of gram-negative bacteria, is the best-studied TLR ligand and is recognized by TLR4 and MD-2, a molecule associ...

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Bibliographische Detailangaben
Hauptverfasser: Akashi, Sachiko, Saitoh, Shin-ichiroh, Wakabayashi, Yasutaka, Kikuchi, Takane, Takamura, Noriaki, Nagai, Yoshinori, Kusumoto, Yutaka, Fukase, Koichi, Kusumoto, Shoichi, Adachi, Yoshiyuki, Kosugi, Atsushi, Miyake, Kensuke
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2003
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194215/
https://ncbi.nlm.nih.gov/pubmed/14517279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20031076
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