T cell receptor binding affinity governs the functional profile of cancer-specific CD8(+) T cells

Antigen-specific T cell receptor (TCR) gene transfer via patient-derived T cells is an attractive approach to cancer therapy, with the potential to circumvent immune regulatory networks. However, high-affinity tumour-specific TCR clonotypes are typically deleted from the available repertoire during...

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Detalhes bibliográficos
Publicado no:Clin Exp Immunol
Main Authors: Tan, M P, Gerry, A B, Brewer, J E, Melchiori, L, Bridgeman, J S, Bennett, A D, Pumphrey, N J, Jakobsen, B K, Price, D A, Ladell, K, Sewell, A K
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Translational
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4408161/
https://ncbi.nlm.nih.gov/pubmed/25496365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cei.12570
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