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Clonotypically similar hybrid αβ T cell receptors can exhibit markedly different surface expression, antigen specificity and cross‐reactivity

Emerging data indicate that particular major histocompatibility complex (MHC)‐bound antigenic peptides can be recognized by identical or near‐identical αβ T cell receptors (TCRs) in different individuals. To establish the functional relevance of this phenomenon, we artificially paired α and β chains...

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Detalhes bibliográficos
Publicado no:Clin Exp Immunol
Main Authors: Motozono, C., Bridgeman, J. S., Price, D. A., Sewell, A. K., Ueno, T.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4449784/
https://ncbi.nlm.nih.gov/pubmed/25721491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cei.12610
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