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Clonotypically similar hybrid αβ T cell receptors can exhibit markedly different surface expression, antigen specificity and cross‐reactivity

Emerging data indicate that particular major histocompatibility complex (MHC)‐bound antigenic peptides can be recognized by identical or near‐identical αβ T cell receptors (TCRs) in different individuals. To establish the functional relevance of this phenomenon, we artificially paired α and β chains...

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Détails bibliographiques
Publié dans:Clin Exp Immunol
Auteurs principaux: Motozono, C., Bridgeman, J. S., Price, D. A., Sewell, A. K., Ueno, T.
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4449784/
https://ncbi.nlm.nih.gov/pubmed/25721491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cei.12610
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