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Immune Cell Profiling of IFN-λ Response Shows pDCs Express Highest Level of IFN-λR1 and Are Directly Responsive via the JAK-STAT Pathway

The interferon lambda (IFN-λ) cytokines have well-known antiviral properties, yet their contribution to immune regulation is not well understood. Epithelial cells represent the major target cell of IFN-λ; peripheral blood mononuclear cells are generally considered nonresponsive, with the exception o...

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Detalhes bibliográficos
Publicado no:J Interferon Cytokine Res
Main Authors: Kelly, Aoife, Robinson, Mark W., Roche, Gerard, Biron, Christine A., O'Farrelly, Cliona, Ryan, Elizabeth J.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5165669/
https://ncbi.nlm.nih.gov/pubmed/27617757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/jir.2015.0169
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