Creating an Artificial Tail Anchor as a Novel Strategy To Enhance the Potency of Peptide-Based HIV Fusion Inhibitors

20 (enfuvirtide) and other peptides derived from the human immunodeficiency virus type 1 (HIV-1) gp41 C-terminal heptad repeat (CHR) region inhibit HIV fusion by binding to the hydrophobic grooves on the N-terminal heptad repeat (NHR) trimer and blocking six-helix-bundle (6-HB) formation. Several st...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Su, Shan, Zhu, Yun, Ye, Sheng, Qi, Qianqian, Xia, Shuai, Ma, Zhenxuan, Yu, Fei, Wang, Qian, Zhang, Rongguang, Jiang, Shibo, Lu, Lu
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2016
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5165219/
https://ncbi.nlm.nih.gov/pubmed/27795416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01445-16
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