Rational improvement of gp41-targeting HIV-1 fusion inhibitors: an innovatively designed Ile-Asp-Leu tail with alternative conformations

Peptides derived from the C-terminal heptad repeat (CHR) of HIV gp41 have been developed as effective fusion inhibitors against HIV-1, but facing the challenges of enhancing potency and stability. Here, we report a rationally designed novel HIV-1 fusion inhibitor derived from CHR-derived peptide (Tr...

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Publicado no:Sci Rep
Main Authors: Zhu, Yun, Su, Shan, Qin, Lili, Wang, Qian, Shi, Lei, Ma, Zhenxuan, Tang, Jianchao, Jiang, Shibo, Lu, Lu, Ye, Sheng, Zhang, Rongguang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5036048/
https://ncbi.nlm.nih.gov/pubmed/27666394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31983
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