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Nonneutralizing Antibodies Induced by the HIV-1 gp41 NHR Domain Gain Neutralizing Activity in the Presence of the HIV Fusion Inhibitor Enfuvirtide: a Potential Therapeutic Vaccine Strategy

A key barrier against developing preventive and therapeutic human immunodeficiency virus (HIV) vaccines is the inability of viral envelope glycoproteins to elicit broad and potent neutralizing antibodies. However, in the presence of fusion inhibitor enfuvirtide, we show that the nonneutralizing anti...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Wang, Qian, Bi, Wenwen, Zhu, Xiaojie, Li, Haoyang, Qi, Qianqian, Yu, Fei, Lu, Lu, Jiang, Shibo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468469/
https://ncbi.nlm.nih.gov/pubmed/25903343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00791-15
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