Adding an Artificial Tail—Anchor to a Peptide-Based HIV-1 Fusion Inhibitor for Improvement of Its Potency and Resistance Profile

Peptides derived from the C-terminal heptad repeat (CHR) of human immunodeficiency virus type 1 (HIV-1) envelope protein transmembrane subunit gp41, such as T20 (enfuvirtide), can bind to the N-terminal heptad repeat (NHR) of gp41 and block six-helix bundle (6-HB) formation, thus inhibiting HIV-1 fu...

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Bibliographic Details
Published in:Molecules
Main Authors: Su, Shan, Ma, Zhenxuan, Hua, Chen, Li, Weihua, Lu, Lu, Jiang, Shibo
Format: Artigo
Language:Inglês
Published: MDPI 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6150406/
https://ncbi.nlm.nih.gov/pubmed/29156603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules22111996
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