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Gene interactions in the DNA damage-response pathway identified by genome-wide RNA-interference analysis of synthetic lethality
Here, we describe a systematic search for synthetic gene interactions in a multicellular organism, the nematode Caenorhabditis elegans. We established a high-throughput method to determine synthetic gene interactions by genome-wide RNA interference and identified genes that are required to protect t...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2004
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC516506/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15326288/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0403131101 |
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