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Identifying collateral and synthetic lethal vulnerabilities within the DNA-damage response
BACKGROUND: A pair of genes is defined as synthetically lethal if defects on both cause the death of the cell but a defect in only one of the two is compatible with cell viability. Ideally, if A and B are two synthetic lethal genes, inhibiting B should kill cancer cells with a defect on A, and shoul...
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| Publicat a: | BMC Bioinformatics |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BioMed Central
2021
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8126165/ https://ncbi.nlm.nih.gov/pubmed/33992077 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-021-04168-7 |
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