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Identifying collateral and synthetic lethal vulnerabilities within the DNA-damage response

BACKGROUND: A pair of genes is defined as synthetically lethal if defects on both cause the death of the cell but a defect in only one of the two is compatible with cell viability. Ideally, if A and B are two synthetic lethal genes, inhibiting B should kill cancer cells with a defect on A, and shoul...

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Detaylı Bibliyografya
Yayımlandı:BMC Bioinformatics
Asıl Yazarlar: Pinoli, Pietro, Srihari, Sriganesh, Wong, Limsoon, Ceri, Stefano
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2021
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8126165/
https://ncbi.nlm.nih.gov/pubmed/33992077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-021-04168-7
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