Synthetic lethal approaches exploiting DNA damage in aggressive myeloma

Ongoing DNA damage is a common feature of epithelial cancers. Here we show that tumor cells derived from multiple myeloma (MM), a disease of clonal plasma cells, demonstrate DNA replicative stress leading to DNA damage. We identified a poor prognosis subset of MM with extensive chromosomal instabili...

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Bibliografiset tiedot
Julkaisussa:Cancer Discov
Päätekijät: Cottini, Francesca, Hideshima, Teru, Suzuki, Rikio, Tai, Yu-Tzu, Bianchini, Giampaolo, Richardson, Paul G., Anderson, Kenneth C., Tonon, Giovanni
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2015
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4560623/
https://ncbi.nlm.nih.gov/pubmed/26080835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-0943
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