Gene interactions in the DNA damage-response pathway identified by genome-wide RNA-interference analysis of synthetic lethality

Here, we describe a systematic search for synthetic gene interactions in a multicellular organism, the nematode Caenorhabditis elegans. We established a high-throughput method to determine synthetic gene interactions by genome-wide RNA interference and identified genes that are required to protect t...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: van Haaften, Gijs, Vastenhouw, Nadine L., Nollen, Ellen A. A., Plasterk, Ronald H. A., Tijsterman, Marcel
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2004
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC516506/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15326288/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0403131101
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