Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation

Protein misfolding and the formation of aggregates are increasingly recognized components of the pathology of human genetic disease and hallmarks of many neurodegenerative disorders. As exemplified by polyglutamine diseases, the propensity for protein misfolding is associated with the length of poly...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Nollen, Ellen A. A., Garcia, Susana M., van Haaften, Gijs, Kim, Soojin, Chavez, Alejandro, Morimoto, Richard I., Plasterk, Ronald H. A.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2004
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC404057/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15084750/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0307697101
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