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Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation
Protein misfolding and the formation of aggregates are increasingly recognized components of the pathology of human genetic disease and hallmarks of many neurodegenerative disorders. As exemplified by polyglutamine diseases, the propensity for protein misfolding is associated with the length of poly...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2004
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC404057/ https://ncbi.nlm.nih.gov/pubmed/15084750 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0307697101 |
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