Synthesis, anti-proliferative activity, SAR study, and preliminary in vivo toxicity study of substituted N,N′-bis(arylmethyl)benzimidazolium salts against a panel of non-small cell lung cancer cell lines

A series of N,N′-bis(arylmethyl)benzimidazolium salts have been synthesized and evaluated for their in vitro anti-cancer activity against select non-small cell lung cancer cell lines to create a structure activity relationship profile. The results indicate that hydrophobic substituents on the salts...

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Veröffentlicht in:Bioorg Med Chem
Hauptverfasser: Shelton, Kerri L., DeBord, Michael A., Wagers, Patrick O., Southerland, Marie R., Williams, Travis M., Robishaw, Nikki K., Shriver, Leah P., Tessier, Claire A., Panzner, Matthew J., Youngs, Wiley J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5164943/
https://ncbi.nlm.nih.gov/pubmed/27876249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.11.009
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