Transcriptional repression by p53 promotes a Bcl-2-insensitive and mitochondria-independent pathway of apoptosis

p53 can induce apoptosis in various ways including transactivation, transrepression and transcription-independent mechanisms. What determines the choice between them is poorly understood. In a rat embryo fibroblast model, caspase inhibition changed the outcome of p53 activation from standard Bcl-2-r...

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Publicat a:Nucleic Acids Res
Autors principals: Godefroy, Nelly, Bouleau, Sylvina, Gruel, Gaëtan, Renaud, Flore, Rincheval, Vincent, Mignotte, Bernard, Tronik-Le Roux, Diana, Vayssière, Jean-Luc
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2004
Matèries:
Articles
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC516049/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15326223/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkh773
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