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Transcriptional repression by p53 promotes a Bcl-2-insensitive and mitochondria-independent pathway of apoptosis

p53 can induce apoptosis in various ways including transactivation, transrepression and transcription-independent mechanisms. What determines the choice between them is poorly understood. In a rat embryo fibroblast model, caspase inhibition changed the outcome of p53 activation from standard Bcl-2-r...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Godefroy, Nelly, Bouleau, Sylvina, Gruel, Gaëtan, Renaud, Flore, Rincheval, Vincent, Mignotte, Bernard, Tronik-Le Roux, Diana, Vayssière, Jean-Luc
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2004
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC516049/
https://ncbi.nlm.nih.gov/pubmed/15326223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh773
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