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Estimates of statistical significance for comparison of individual positions in multiple sequence alignments

BACKGROUND: Profile-based analysis of multiple sequence alignments (MSA) allows for accurate comparison of protein families. Here, we address the problems of detecting statistically confident dissimilarities between (1) MSA position and a set of predicted residue frequencies, and (2) between two MSA...

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Main Authors: Sadreyev, Ruslan I, Grishin, Nick V
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2004
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC516024/
https://ncbi.nlm.nih.gov/pubmed/15296518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-5-106
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