Exon junction complex proteins bind nascent transcripts independently of pre-mRNA splicing in Drosophila melanogaster

Although it is currently understood that the exon junction complex (EJC) is recruited on spliced mRNA by a specific interaction between its central protein, eIF4AIII, and splicing factor CWC22, we found that eIF4AIII and the other EJC core proteins Y14 and MAGO bind the nascent transcripts of not on...

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Veröffentlicht in:eLife
Hauptverfasser: Choudhury, Subhendu Roy, Singh, Anand K, McLeod, Tina, Blanchette, Marco, Jang, Boyun, Badenhorst, Paul, Kanhere, Aditi, Brogna, Saverio
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2016
Schlagworte:
Genes and Chromosomes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5158136/
https://ncbi.nlm.nih.gov/pubmed/27879206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.19881
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