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Myofilament Calcium Sensitivity: Mechanistic Insight into TnI Ser-23/24 and Ser-150 Phosphorylation Integration

Troponin I (TnI) is a major regulator of cardiac muscle contraction and relaxation. During physiological and pathological stress, TnI is differentially phosphorylated at multiple residues through different signaling pathways to match cardiac function to demand. The combination of these TnI phosphory...

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Pubblicato in:Front Physiol
Autori principali: Salhi, Hussam E., Hassel, Nathan C., Siddiqui, Jalal K., Brundage, Elizabeth A., Ziolo, Mark T., Janssen, Paul M. L., Davis, Jonathan P., Biesiadecki, Brandon J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5156683/
https://ncbi.nlm.nih.gov/pubmed/28018230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2016.00567
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