Identification of the Functional Variant(s) that Explain the Low-Density Lipoprotein Receptor (LDLR) GWAS SNP rs6511720 Association with Lower LDL-C and Risk of CHD

BACKGROUND: The Low-Density Lipoprotein Receptor (LDLR) SNP rs6511720 (G>T), located in intron-1 of the gene, has been identified in genome-wide association studies (GWAS) as being associated with lower plasma levels of LDL-C and a lower risk of coronary heart disease (CHD). Whether or not rs6511...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Fairoozy, Roaa Hani, White, Jon, Palmen, Jutta, Kalea, Anastasia Z., Humphries, Steve E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5156384/
https://ncbi.nlm.nih.gov/pubmed/27973560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0167676
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