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Triciribine increases LDLR expression and LDL uptake through stabilization of LDLR mRNA

Low-density lipoprotein receptor (LDLR) is a key regulator of the metabolism of plasma low-density lipoprotein cholesterol (LDL-C), the elevated levels of which are associated with an increased risk of cardiovascular disease. Therefore, enhancing LDLR expression represents a potent treatment strateg...

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Foilsithe in:Sci Rep
Main Authors: Bjune, Katrine, Wierød, Lene, Naderi, Soheil
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2018
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6212527/
https://ncbi.nlm.nih.gov/pubmed/30385871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-34237-6
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