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CryoEM structure of the spliceosome immediately after branching
Pre-mRNA splicing proceeds by two consecutive trans-esterification reactions via a lariat-intron intermediate. We present the 3.8Å cryoEM structure of the spliceosome immediately after lariat formation. The 5’-splice site is cleaved but remains close to the catalytic Mg(2+) site in the U2/U6 snRNA t...
में बचाया:
| में प्रकाशित: | Nature |
|---|---|
| मुख्य लेखकों: | , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2016
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5156311/ https://ncbi.nlm.nih.gov/pubmed/27459055 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature19316 |
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