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Single heteroatom substitutions in the efavirenz oxazinone ring impact metabolism by CYP2B6
Previously, we observed that the oxazinone ring is important for CYP2B6 activity toward efavirenz ((4S)-6-Chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one), a CYP2B6 substrate used to treat HIV. Here, to further understand the structural characteristics of efav...
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| Publicado no: | ChemMedChem |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5155582/ https://ncbi.nlm.nih.gov/pubmed/27860311 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201600519 |
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