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Functional Site Discovery in a Sulphur Metabolism Enzyme Using Directed Evolution

In human pathogens, the sulphate assimilation pathway provides reduced sulphur for biosynthesis of essential metabolites including cysteine and low-molecular weight thiol compounds. Sulfonucleotide reductases (SRs) catalyze the first committed step of sulphate reduction. In this reaction, activated...

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Publicat a:Chembiochem
Autors principals: Paritala, Hanumantharao, Palde, Prakash B., Carroll, Kate S.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5155445/
https://ncbi.nlm.nih.gov/pubmed/27411165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201600264
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