AAV Mediated Gene Delivery Attenuates Neuroinflammation in Feline Sandhoff Disease

Sandhoff disease (SD) is a lysosomal storage disorder characterized by the absence of hydrolytic enzyme β-N-acetylhexosaminidase (Hex), which results in storage of GM2 ganglioside in neurons and unremitting neurodegeneration. Neuron loss initially affects fine motor skills, but rapidly progresses to...

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Detalhes bibliográficos
Publicado no:Neuroscience
Main Authors: Bradbury, Allison M, Peterson, Tiffany A, Gross, Amanda L, Wells, Stephen Z, McCurdy, Victoria J, Wolfe, Karen G, Dennis, John C, Brunson, Brandon L, Gray-Edwards, Heather, Randle, Ashley N, Johnson, Aime K, Morrison, Edward E, Cox, Nancy R, Baker, Henry J, Sena-Esteves, Miguel, Martin, Douglas R
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5154837/
https://ncbi.nlm.nih.gov/pubmed/27793778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2016.10.047
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