Stabilization of Human Serum Albumin by the Binding of Phycocyanobilin, a Bioactive Chromophore of Blue-Green Alga Spirulina: Molecular Dynamics and Experimental Study

Phycocyanobilin (PCB) binds with high affinity (2.2 x 10(6) M(-1) at 25°C) to human serum albumin (HSA) at sites located in IB and IIA subdomains. The aim of this study was to examine effects of PCB binding on protein conformation and stability. Using 300 ns molecular dynamics (MD) simulations, UV-V...

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Pubblicato in:PLoS One
Autori principali: Radibratovic, Milica, Minic, Simeon, Stanic-Vucinic, Dragana, Nikolic, Milan, Milcic, Milos, Cirkovic Velickovic, Tanja
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5154526/
https://ncbi.nlm.nih.gov/pubmed/27959940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0167973
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