Stabilization of Human Serum Albumin by the Binding of Phycocyanobilin, a Bioactive Chromophore of Blue-Green Alga Spirulina: Molecular Dynamics and Experimental Study

Phycocyanobilin (PCB) binds with high affinity (2.2 x 10(6) M(-1) at 25°C) to human serum albumin (HSA) at sites located in IB and IIA subdomains. The aim of this study was to examine effects of PCB binding on protein conformation and stability. Using 300 ns molecular dynamics (MD) simulations, UV-V...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Radibratovic, Milica, Minic, Simeon, Stanic-Vucinic, Dragana, Nikolic, Milan, Milcic, Milos, Cirkovic Velickovic, Tanja
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2016
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5154526/
https://ncbi.nlm.nih.gov/pubmed/27959940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0167973
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