Stabilization of Human Serum Albumin by the Binding of Phycocyanobilin, a Bioactive Chromophore of Blue-Green Alga Spirulina: Molecular Dynamics and Experimental Study

Phycocyanobilin (PCB) binds with high affinity (2.2 x 10(6) M(-1) at 25°C) to human serum albumin (HSA) at sites located in IB and IIA subdomains. The aim of this study was to examine effects of PCB binding on protein conformation and stability. Using 300 ns molecular dynamics (MD) simulations, UV-V...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Radibratovic, Milica, Minic, Simeon, Stanic-Vucinic, Dragana, Nikolic, Milan, Milcic, Milos, Cirkovic Velickovic, Tanja
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5154526/
https://ncbi.nlm.nih.gov/pubmed/27959940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0167973
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