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In Vivo Reconstitution of the Negative Feedback in Nitric Oxide/cGMP Signaling: Role of Phosphodiesterase Type 5 Phosphorylation

Most effects of the messenger molecule nitric oxide (NO) are mediated by cGMP, which is formed by NO-sensitive guanylyl cyclase (GC) and degraded by phosphodiesterases (PDEs). In platelets, NO elicits a spike-like cGMP response and causes a sustained desensitization. Both characteristics have been a...

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Autori principali: Mullershausen, Florian, Russwurm, Michael, Koesling, Doris, Friebe, Andreas
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Cell Biology 2004
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC515337/
https://ncbi.nlm.nih.gov/pubmed/15240816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E03-12-0890
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