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In Vivo Reconstitution of the Negative Feedback in Nitric Oxide/cGMP Signaling: Role of Phosphodiesterase Type 5 Phosphorylation
Most effects of the messenger molecule nitric oxide (NO) are mediated by cGMP, which is formed by NO-sensitive guanylyl cyclase (GC) and degraded by phosphodiesterases (PDEs). In platelets, NO elicits a spike-like cGMP response and causes a sustained desensitization. Both characteristics have been a...
Shranjeno v:
| izdano v: | Mol Biol Cell |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Cell Biology
2004
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC515337/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15240816/ https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.E03-12-0890 |
| Oznake: |
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