Buried Hydrogen Bond Interactions Contribute to the High Potency of Complement Factor D Inhibitors

[Image: see text] Aberrant activation of the complement system is associated with diseases, including paroxysmal nocturnal hemoglobinuria and age-related macular degeneration. Complement factor D is the rate-limiting enzyme for activating the alternative pathway in the complement system. Recent deve...

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Bibliografske podrobnosti
izdano v:ACS Med Chem Lett
Main Authors: Yang, Chao-Yie, Phillips, James G., Stuckey, Jeanne A., Bai, Longchuan, Sun, Haiying, Delproposto, James, Brown, William Clay, Chinnaswamy, Krishnapriya
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2016
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5151139/
https://ncbi.nlm.nih.gov/pubmed/27994744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00299
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