Contribution of hydrogen bonds to protein stability

Our goal was to gain a better understanding of the contribution of the burial of polar groups and their hydrogen bonds to the conformational stability of proteins. We measured the change in stability, Δ(ΔG), for a series of hydrogen bonding mutants in four proteins: villin headpiece subdomain (VHP)...

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Autori principali: Pace, C Nick, Fu, Hailong, Fryar, Katrina Lee, Landua, John, Trevino, Saul R, Schell, David, Thurlkill, Richard L, Imura, Satoshi, Scholtz, J Martin, Gajiwala, Ketan, Sevcik, Jozef, Urbanikova, Lubica, Myers, Jeffery K, Takano, Kazufumi, Hebert, Eric J, Shirley, Bret A, Grimsley, Gerald R
Natura: Artigo
Lingua:Inglês
Pubblicazione: Wiley-Blackwell 2014
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4005716/
https://ncbi.nlm.nih.gov/pubmed/24591301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2449
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