Urea denatured state ensembles contain extensive secondary structure that is increased in hydrophobic proteins

The goal of this article is to gain a better understanding of the denatured state ensemble (DSE) of proteins through an experimental and computational study of their denaturation by urea. Proteins unfold to different extents in urea and the most hydrophobic proteins have the most compact DSE and con...

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Detalhes bibliográficos
Main Authors: Nick Pace, C, Huyghues-Despointes, Beatrice M P, Fu, Hailong, Takano, Kazufumi, Scholtz, J Martin, Grimsley, Gerald R
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2868236/
https://ncbi.nlm.nih.gov/pubmed/20198681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.370
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