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Increasing protein stability: Importance of ΔC(p) and the denatured state

Increasing the conformational stability of proteins is an important goal for both basic research and industrial applications. In vitro selection has been used successfully to increase protein stability, but more often site-directed mutagenesis is used to optimize the various forces that contribute t...

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Detalhes bibliográficos
Main Authors: Fu, Hailong, Grimsley, Gerald, Scholtz, J Martin, Pace, C Nick
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2868246/
https://ncbi.nlm.nih.gov/pubmed/20340133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.381
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