RhoE Inhibits Cell Cycle Progression and Ras-Induced Transformation

Rho GTPases are major regulators of cytoskeletal dynamics, but they also affect cell proliferation, transformation, and oncogenesis. RhoE, a member of the Rnd subfamily that does not detectably hydrolyze GTP, inhibits RhoA/ROCK signaling to promote actin stress fiber and focal adhesion disassembly....

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Bibliographic Details
Main Authors: Villalonga, Priam, Guasch, Rosa M., Riento, Kirsi, Ridley, Anne J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC515038/
https://ncbi.nlm.nih.gov/pubmed/15340047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.18.7829-7840.2004
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