Molecular basis for the broad substrate selectivity of a peptide prenyltransferase

The cyanobactin prenyltransferases catalyze a series of known or unprecedented reactions on millions of different substrates, with no easily observable recognition motif and exquisite regioselectivity. Here we define the basis of broad substrate tolerance for the otherwise uncharacterized TruF famil...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Hao, Yue, Pierce, Elizabeth, Roe, Daniel, Morita, Maho, McIntosh, John A., Agarwal, Vinayak, Cheatham, Thomas E., Schmidt, Eric W., Nair, Satish K.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5150373/
https://ncbi.nlm.nih.gov/pubmed/27872314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1609869113
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