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Interactions of divalent cations with calcium binding sites of BK channels reveal independent motions within the gating ring

Large-conductance voltage- and calcium-activated K(+) (BK) channels are key physiological players in muscle, nerve, and endocrine function by integrating intracellular Ca(2+) and membrane voltage signals. The open probability of BK channels is regulated by the intracellular concentration of divalent...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Miranda, Pablo, Giraldez, Teresa, Holmgren, Miguel
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5150367/
https://ncbi.nlm.nih.gov/pubmed/27872281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1611415113
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