Skin Aging-Dependent Activation of the PI3K Signaling Pathway via Downregulation of PTEN Increases Intracellular ROS in Human Dermal Fibroblasts

Reactive oxygen species (ROS) play a major role in both chronological aging and photoaging. ROS induce skin aging through their damaging effect on cellular constituents. However, the origins of ROS have not been fully elucidated. We investigated that ROS generation of replicative senescent fibroblas...

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Veröffentlicht in:Oxid Med Cell Longev
Hauptverfasser: Noh, Eun-Mi, Park, Jinny, Song, Hwa-Ryung, Kim, Jeong-Mi, Lee, Minok, Song, Hyun-Kyung, Hong, On-Yu, Whang, Pyoung H., Han, Myung-Kwan, Kwon, Kang-Beom, Kim, Jong-Suk, Lee, Young-Rae
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi Publishing Corporation 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5149682/
https://ncbi.nlm.nih.gov/pubmed/28003865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/6354261
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