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E-cadherin downregulation sensitizes PTEN-mutant tumors to PI3Kβ silencing
Alterations in phosphatidylinositol 3-kinase (PI3K) and in PTEN (phosphatase and tensin homolog), the negative regulator of the PI3K pathway, are found in nearly half of human tumors. As PI3Kβ, the main isoform activated in PTEN-mutant tumors, has kinase-dependent and -independent activities, we com...
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| Publicado no: | Oncotarget |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Impact Journals LLC
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5356644/ https://ncbi.nlm.nih.gov/pubmed/27863432 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13414 |
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