Skin Aging-Dependent Activation of the PI3K Signaling Pathway via Downregulation of PTEN Increases Intracellular ROS in Human Dermal Fibroblasts

Reactive oxygen species (ROS) play a major role in both chronological aging and photoaging. ROS induce skin aging through their damaging effect on cellular constituents. However, the origins of ROS have not been fully elucidated. We investigated that ROS generation of replicative senescent fibroblas...

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Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Main Authors: Noh, Eun-Mi, Park, Jinny, Song, Hwa-Ryung, Kim, Jeong-Mi, Lee, Minok, Song, Hyun-Kyung, Hong, On-Yu, Whang, Pyoung H., Han, Myung-Kwan, Kwon, Kang-Beom, Kim, Jong-Suk, Lee, Young-Rae
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5149682/
https://ncbi.nlm.nih.gov/pubmed/28003865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/6354261
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